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In comparison, the NE-low variant group is associated with slightly larger cells displaying distinct cell borders and prominent nucleoli

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In particular, glucose-6-phosphate 1-dehydrogenase (G6PD), the rate-limiting enzyme of oxPPP, was significantly upregulated and is involved in the conversion of glucose 6-phosphate to 6-phosphoglucono-1,5-lactone, with concomitant production of NADPH [60]

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