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Pharm Res 18:807813

Multivariable Cox proportional hazards regression was used to identify factors associated with overall survival, defined as the time from diagnosis to death or last follow-up

Ethics declarations Ethics approval and consent to participate This research received approval from the National Center for Health Statistics Research Ethics Review Board, and participants signed informed consent forms (Protocol #201117)

Signalling within the cancer cells Numerous molecular pathways affecting malignant cholangiocytes have been identified, leading to the sub-classification of CCA into inflammatory or proliferative classes characterized by the induction of pro-inflammatory signals and the activation of oncogenic cascades 1,80,123