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During Phase 1 detoxification, a family of enzymes known as Cytochrome P450 (CYP450) modifies toxins through oxidation

J Affect Disord 279:417425 Stang A (2010) Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses

The tolerance level varies from person to person

Eur J Clin Pharmacol 80:1137 Yousra M, Elsherbiny NM, El-Shafey M, Said E (2020) The interplay of the inhibitory effect of nifuroxazide on NF-B/STAT3 signaling attenuates acetic acid-induced ulcerative colitis in rats