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On the one hand, when the WNT pathway is activated, ICAT blocks the interaction of -catenin-APC and inhibits the degradation of -catenin by competing with APC for the binding site of -catenin

H., Wakuta, M., & Kimura, K

Users stopping vitamin C serums generally report gradual benefit decline over 2-4 months with antioxidant protection loss occurring quickly (days to weeks), skin brightness fading over 1-2 months returning toward baseline, and collagen-related firmness improvements showing variable persistence with 30-50% benefit retention long-term for consistent users

10.1101/gad.14.10.1181 20 LiJ.ZhuP.ChenY.ZhangS.ZhangZ.ZhangZ.et al (2022)