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The most common long-term side effects of chemotherapy include fatigue, insomnia, peripheral neuropathy, cognitive impairment, oestrogen deprivation, cardiotoxicity, and the development of secondary malignancies

Despite normalization of plasma homocysteine concentration, administration of folic acid, vitamin B 6 , and vitamin B 12 for 6 months was insufficient to restore normal vascular function in monkeys maintained for 17 months on an atherosclerotic diet that produced both hypercholesterolemia and hyperhomocysteinemia (Lentz et al, 1997)