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First try simulating a typical expected result for a multiple day patch using a dose of 5,400 g (5.4 mg) over 72 hours with kel = 0.289 hr -1 and V = 87.5 L (1.25 L/kg)

Prakash Rao C, David Krupadanam GL

Specifically, this included increased ( Egr, Nos, Srf, and Kras ) or decreased ( Egr, Vegfr, and Plc ) gene expression, while Akt1 gene expression remained unchanged (Vukojevic et al., 2018)