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7 Therapeutic approaches to mitigate BBB dysfunction and cognitive decline Intestinal ischemiareperfusion (I/R) injury and the resulting systemic inflammation can severely compromise the bloodbrain barrier (BBB), leading to cognitive dysfunction (Zhang et al., 2024b)

Treatment with HM-BPT in a 4T1 xenograft model resulted in significant tumor suppression, infiltration of CTLs, as well as M1 phenotype repolarization and activation of the stimulator of IFN genes (STING) pathway in macrophages [205]

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Antioxidants 8:357 Becker N-P, Martitz J, Renko K et al (2014) Hypoxia reduces and redirects selenoprotein biosynthesis