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Drinda, S., S

When the mitochondrial antioxidant system is damaged and ROS cannot be eliminated from cells, lipid peroxidation is mediated through the Fenton reaction [7, 82]

His and Arg act to help create the reactive environment, and Cys once again acts as the reaction center by using a thioester help hold a carboxyl group until the amine of a Lysine can perform a nucleophilic attack to transfer the protein and form the isopeptide bond