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Description

For each mouse, total injection volumes never exceeded 100 L

The single chain pro-polypeptide is proteolytically processed by convertases to yield a mature a (heavy chain 55 KDa), and (light chain 34 KDa) heterodimer, which are bound together by a disulfide link (Stella and Comoglio, 1999

The percentages of patients who withdrew from the study due to adverse events were 7.1%, 7.2%, and 3.0% in the two Reclast groups and placebo group, respectively