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Figure 6 As can be seen in Table 2 , reduced glucose together with depleted citrate (TCA intermediates) were observed in ESCC tumor tissues, reflecting an enhanced activation of glycolysis, which increases the demand and utilization of glucose and TCA intermediates to promote tumor growth ( Cancer cells typically exhibit high rates of anabolic metabolism, by which they absorb large amounts of nutrients to promote TCA cycling and oxidative phosphorylation

10.1038/337247a0 Nature 96 NicholB

Blood-brain barrier leakage during early epileptogenesis is associated with rapid remodeling of the neurovascular unit

The rationale behind combining them is rooted in cellular metabolism