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Progressive multiple sclerosis: pathology and pathogenesis

This condition involves multiple disruptions in cardiac energy metabolism, including substrate utilization, mitochondrial function, and ATP synthesis

It could also induce overexpression of bactericidal/permeability-increasing protein (BPI) and antimicrobial peptide LL37 genes, increasing the ability of macrophages to eliminate bacterial infection (Jurez et al., 2018)

Further research should investigate how they influence key immune factors such as NK cells, neutrophils, goblet cell-stimulated mucin production, and histone deacetylase regulation in lupus models