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Voltage-gated ion channels enable the selective influx and efflux of ions, such as sodium, potassium, and calcium, across the BBB, thereby contributing to the maintenance of electrochemical gradients [119]

For this reason cobalamin is the term used to refer to compounds having vitamin B 12 activity

Yue-Yu Gu, [email protected] These authors have contributed equally to this work This article was submitted to Renal Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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