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Concurrently, the reprogramming of metabolism, altering intracellular and extracellular metabolites affecting gene expression, differentiation, and the tumour microenvironment, is increasingly being studied, and alterations in metabolic pathways are becoming hallmarks of cancer

Nevertheless, efforts focusing on vaccines, immunotherapeutics, CRISPR, probiotics, microbial therapies, phage therapy, and fecal transplants are gaining attention

Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia

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