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Furthermore, the activation of Notch signaling has been observed in I/R-induced AKI models, subsequently triggering the activation of p21 and p16 INK4a and intensifying interstitial fibrosis development [65]

ligands selected from the group consisting of: glutathione (GSH or gamma-glutamylcysteinylglycine), S-(p-bromobenzyl)glutathione, gamma-(L-gamma-azaglutamyl)-S-(p-bromobenzyl)-L-c y s t e i n y l g l y c i n , S- Butylglutathione, S-Decylglutathione, Glutathione reduced ethyl ester, Glutathionesulfonic acid, S-Hexylglutathione, S-Lactoylglutathione, S- Methylglutathione, S-(4-Nitrobenzyl)glutathione, S-Octy Ri and R 2 are independently selected from the group consisting of H, linear or branched alkyl (1-25C), aralkyl (6-26C), cycloalkyl (6-25C), heterocycles (6-20C), ethers or polyethers (3-25C), and where Ri-R 2 together have 2-20C atoms and form a macrocycle with the remainder of formula I

GlutaTonic is formulated with well-tolerated ingredients at standard supplement doses

Muleiro AlvarezMCano-HerreraGOsorio MartnezMFVega Gonzales-PortilloJMonroyGRMurguiondo PrezRet al