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The actions of IGF-I and IGF-IR in skeletal development Skeletal development is a highly coordinated process, which requires initial recruitment and migration of relevant precursors to future bone sites, commitment of the precursors to chondrogenic and osteogenic lineages and their terminal differentiation to acquire a complete set of cartilage- or bone-forming functions (24,25)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 130.Fanning AS, Little BP, Rahner C, Utepbergenov D, Walther Z, Anderson JM