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Mild ischemia (CBF greater than 30 ml/100 g/min) does not normally cause cell death during the first 6 h after injury, moderate ischemia (CBF between 12 and 30 ml/100 g/min) reaches the threshold of viability in 3 h, and severe ischemia (CBF lower than 12 ml/100 g/min) causes cell death in less than an hour (Sakoh et al., 2000)