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Since extracellular NAD + can be degraded into adenosine, extracellular NAD + might exert some of its effects via adenosine, which can induce profibrotic effects via adenosine receptor A2a on dermal fibroblasts 60

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The vast majority of information comes from in-vitro and animal studies

This is in line with what was previously reported ( In order to determine whether circulating Daratumumab in the combination therapy patient is functional, we performed an in vitro complement dependent cytotoxicity (CDC) assay with NK92 target cells ( Supplementary Figure 4B )