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These findings were reinforced by a systematic review and meta-analysis by Henderson et al., which consolidated data from multiple neonatal studies and concluded that melatonin supplementation was associated with reduced oxidative damage and improved clinical outcomes (Henderson et al., 2018)

In glial cells reuptaken glutamate is converted to glutamine by glutamine synthetase thus ending neurotransmission, offering neuroprotection and preventing excitotoxicity