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doi: 10.1007/s00125-021-05435-1 18 XuJLloydDJHaleCStanislausSChenMSivitsGet al

A meta-analysis focused on complex reproductive histories confirms that for women over 35 with DOR, PCOS, or those undergoing ART cycles, meta-analyses can show meaningful marker improvements, but evidence certainty remains low and effects vary by subgroup and duration

Although physical examination and laboratory evaluation of most men with ED may not reveal the exact diagnosis, clinical and biochemical evaluation presents an opportunity to identify comorbid conditions [328]

Aside from the traditional protein-based biomarkers, there is an increased interest on the development of analysis methods for newer metabolite-based biomarkers, including TMAO [3]