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Indole-3-carbinol (I3C) and its metabolite DIM exert hormone-modulatory effects by shifting estrogen metabolism from the genotoxic 16-hydroxyestrone pathway toward the less carcinogenic 2-hydroxyestrone pathway, enhancing CYP1A1/1A2 activity, and simultaneously downregulating ER and upregulating ER expression, which together lead to suppression of estrogen-driven proliferation and sensitization of tumours to endocrine therapies (191)

A slightly lower concentration of 8-oxo-dg was found in the A-GSH group.[15] SOD-1: Superoxide is one of the main reactive oxygen species in the cell, and, as such, SOD serves a key antioxidant role

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Their substantial regional heterogeneity challenges the concept of a uniform astrocytic phenotype, with direct implications for metabolic support