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Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice

Laboratory studies have examined its behavior in relation to gene expression, enzymatic activity, and cellular repair processes under controlled conditions

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After TBI, activation of microglia and the cytokines released by damaged cells destroy tight junctions through impairment of BBB endothelial cells, pericytes, astrocytes, and through the synthesis of tight junction proteins