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In CRC, PHGDH is markedly upregulated: Cullin 4A (Cul4A)-mediated PHGDH ubiquitination enhances its stability and activity, elevating SAM levels to promote metastasis via SETD1A-dependent histone methylation of cell adhesion genes (191)

These disorders include neuromyelitis optica (NMO, also known as unilateral optic neuritis), isolated or recurrent transverse myelitis, longitudinally extensive transverse myelitis or isolated brain lesions with or without detectable anti AQP4-IgG autoantibody