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Very few peptide drugs are available in oral formulations due to the challenges of gastrointestinal degradation and poor absorption

Given that GMSCs are of a neural crest origin [18, 35, 36], our previous studies have shown that ex vivo expanded GMSCs could directly convert to NCSC-like or neural progenitor-like cells under defined culture conditions, which exerted better therapeutic effects on axonal regeneration and functional recovery of injured peripheral nerves than their parental GMSC counterparts [34, 41]

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Caldwell B, Aldington S, Weatherall M, Shirtcliffe P, Beasley R