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Examples of major enzymes include cytochromes (CYP) P450, carboxyl esterase (CES), and flavin-dependent monooxygenase (FMO) (Enlo-Scott et al

In those who require acetylcysteine, 2 hours before completion of infusion check ALT/AST and paracetamol concentration (in those with high initial paracetamol concentrations greater than double the 150mg at 4 h nomogram line) to determine need for ongoing acetylcysteine

Any visible particles, specks, or strands mean the vial is compromised