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This connection suggests m6A methylation also plays an important role in the fine tuning of gene expression in AUD, and understanding how cells manage their one-carbon metabolism and output of SAM for the all methylation mechanisms discussed herein are perhaps indispensable to developing treatments for AUD

It also restricts the infiltration of peripheral immune cells into the brain

For this reason, we explored the efficacy of combining RT with sertraline, a repurposed SHMT inhibitor [19]

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