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Modern medicine has extensively validated its therapeutic potential, leading to its widespread use in the prevention and treatment of various conditions, including inflammatory diseases, infectious diseases, respiratory disorders, cardiovascular diseases, neurological disorders, cancers, mental health issues, and metabolic disorders ( Curcumin, or (1E,6E)-1,7-bis (4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, is a symmetric molecule known as diferuloyl methane (MW368.38 g mol 1 ) (Priyadarsini, 2014)

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Off-target effects of gRNAs are therefore lethal already at the blood stage by causing irreparable chromosome damage, presumably at the ring stage, when no repair template in the form of other chromosome copies is available