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It also attenuates systemic inflammation caused by the enhancement of TLR4 and myeloid differentiation factor 88 (MyD88), suppressing the release of inflammatory factors such as TNF- and IL-1

[DOI] [PMC free article] [PubMed] [Google Scholar] 634.Valetdinova KR, Malankhanova TB, Zakian SM, Medvedev SP

The following criteria were used for ligand preparation: (i) an OPLS3 force field, (ii) the generation of all possible ionization states at pH 7.0 2.0, (iii) the desalt option, (iv) the generation of a tautomer for all conformers, and (v) the generation of one low-energy conformer per ligand

Clin Exp Pharmacol Physiol 29:10181023 OShea RD, Lau CL, Farso MC, Diwakarla S, Zagami CJ, Svendsen BB, Feeney SJ, Callaway JK, Jones NM, Pow DV, Danbolt NC, Jarrott B, Beart PM (2006) Effects of lipopolysaccharide on glial phenotype and activity of glutamate transporters: evidence for delayed up-regulation and redistribution of GLT-1