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In such an example, if cognitive performance negatively correlates with a general increase in proinflammatory cytokines, this is indirect evidence that neuroinflammation is part of brain fog. This approach moves the focus of cytokine studies away from whether a distinct cytokine profile exists in ME/CFS patients, and toward the use of cytokines for understanding the mechanisms of key symptoms

[DOI] [PubMed] [Google Scholar] 158.Festuccia C., Angelucci A., Gravina G.L., Biordi L., Millimaggi D., Muzi P., Vicentini C., Bologna M

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Silencing of Lsd1 facilitated inflammatory gene expression and enhanced VSMC-monocyte binding in nondiabetic VSMCs