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Y., Wille E., et al

This reaction is essential for linking folate metabolism with methionine homeostasis

Moreover, the TFR1, FPN, and DMT1 transcriptions are controlled by HIF via binding to their hypoxia-responsive elements, serving as a potent transcription factor

These limitations include cytotoxicity, immune rejection, regulatory obstacles, senescence and inflammation, and limited targeting precision [10, 58, 59]