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In certain illustrative, but non-limiting embodiments, antibody-drug conjugates can be prepared using, for example, (3-Acetylphenyl)acetic acid (AcPAc) or 4-mercapto-4-methyl-pentanoic acid (Amide) as the linker molecule

Indeed, nearly half of the subjects did not identify tinnitus as part of their MdDS experience, while some subjects strongly or even very strongly associated it with their MdDS severity

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75 Evidence from experimental models has demonstrated that tinnitus is associated with elevated neuronal activity within multiple structures of the central auditory pathway