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Mechanistically, it was found that P53 can inhibit ferroptosis in hepatocellular carcinoma cells by promoting the entry of DPP4 into the nucleus and forming a DPP4-P53 complex

wherein L236 is substituted with either an A, C, D, E, F, G, H, I, K, M, N, P, Q, R, S, T, V, W, or Y

The protein level of significantly increased p16 was confirmed in keloid lesions and fibroblasts based on western blot analysis ( p = 0.0007, p = 0.03