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While congenital and traumatic cataracts result from genetic mutations or physical injury, ARCs stem from progressive lens opacification associated with multiple factors, including oxidative stress, protein aggregation, and critically, DNA methylation-mediated silencing of protective genes in LECs (Table SIV) (108,235,236)

While oxidation is a normal process, excessive oxidative stress can be a precursor to several diseases , including: Diabetes Cancer Rheumatoid arthritis In this context, glutathione stands out for its antioxidant properties

We also outline current studies that support the involvement of the gut microbiota and mesenchymal cells in the development and progression of UC, with implications for therapeutic development

They can be utilized in combination with a comprehensive weight management program that consists of a balanced diet and frequent exercise, but they are not a stand-alone weight loss solution