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The excessive increase of free radicals leads to oxidative stress, which further impairs various functions of nerve cells, such as reducing intracellular ATP production, which in turn affects cell membrane phospholipid asymmetry, synaptic remodeling, nerve cell mitochondrial transport, neurite length and intracellular calcium ion concentration, ultimately leading to nerve cell death and cognitive decline (Butterfield, 2018)

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NaBPC157 (administered either in the ng or g/kg range, i.p.) significantly reduced the reactions in the writhing (inflammatory and non-inflammatory, prostaglandin-dependent and independent) and tail pinching tests