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Research dose/evidence: Some cosmetic studies show Acmella extract (the source of spilanthol) improves wrinkle appearance, but there are fewer large clinical trials than for retinoids or peptides (there never are with botanical extracts)

Of note, nanoparticles derived from natural products are particularly valued for their abundant sources, low cost, renewability, excellent biodegradability, and biocompatibility [27,28,29]

Pharmacological agents such as ergothioneine acid reduce the SSG of NF-B-dependent Wnt5a-sFlt1, improving post-MI outcomes by preserving GRX1 activity and myocardial integrity (84)