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In contrast to intraluminal vesicle formation, in which ESCRT-0 recognizes ubiquitylated endocytosed proteins to initiate sequential ESCRT-IIIIII polymerization 11 , ESCRT-0 is dispensable for lysosomal membrane repair, and ubiquitylation is instead detected during bulk removal of irreversibly damaged lysosomes (lysophagy) 2,7,12,13

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Prolonged space missions can result in retinal and optic nerve head edema, accommodation loss due to total cranial nerve III palsy, internal ophthalmoplegia, or paralysis induced by cycloplegic drops and lorazepam, leading to functional hyperopia