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Effects of quercetin on methotrexate-induced nephrotoxicity in rats

Based on the conservative sequence of Nrf2, Nrf2 can be divided into six structural-functional domains, named Neh1-Neh6 ( Figure 1 Kelch-like ECH-related protein-1 (Keap1) is a specific receptor for Nrf2 and the first major inhibitor of Nrf2, mainly present in the cytoplasm