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The FSP1-CoQ10-NAD(P)H pathway exists as a stand-alone parallel system, which co-operates with System X c /GSH/GPX4 axis to suppress phospholipid peroxidation and ferroptosis (Jo et al., 2022)

Rheumatoid arthritis (RA) RA is characterized by chronic inflammation of the joints, damage to cartilage and bone [140]

However, secondary GBMs often exhibit tumor protein p53 (TP53) mutations that develop in younger patients [41, 48]

Acknowledgements We would like to express our sincere gratitude to Professor Zhentao Zhang from the Department of Neurology at Renmin Hospital, Wuhan University, for his invaluable guidance and support throughout this research