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10.1016/j.devcel.2014.11.012 14 DeponteM

Since A and B rings are fused in cis configuration, the planar structure of the steroid nucleus is curved, and it is possible to identify: a concave side, which is hydrophilic because the hydroxyl groups and the carboxyl group of the side chain, with or without the linked amino acid, are oriented towards it

By contrast, HR /HER2 + primary tumours have the lowest probability of subtype switching, probably owing to their strong neurotropic properties, 78 since HER2 + phenotype itself is reported to retain high brain-metastasis tendency

These experiments confirmed that cagrilintide is a potent dual agonist, activating both receptor types, which is crucial for its therapeutic effect on reducing food intake and body weight, as demonstrated in preclinical rat models