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Figure 5 4.2 Burn wound repair Burn injuries, typically resulting from thermal exposure, cause significant skin damage and initiate a complex healing cascade comprising four overlapping phases: coagulation and hemostasis, inflammation, tissue proliferation and remodeling, and scar formation (34)

In addition, excessive APAP upregulates TNF-, TGF-, IL-6 and platelet-derived growth factor (PDGF) -B levels in liver tissues of ecto-nucleotide triphosphate diphosphohydrolase-2 (NTPDase2) deficient mice, thereby aggravating AILI and increasing hepatic necrosis [232]

Similarly, it also reduced muscle contraction induced by potassium chloride and carbachol