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During plaque formation, foam cell deathprimarily from ferroptosis and autophagyaccelerates atherosclerotic plaque development

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In the process, S-adenosylhomocysteine is formed, which is then further metabolized to adenosine and homocysteine

For those with positive GPX4 expression, we categorized GPX4 + if 5% to 24% of cells were positive, GPX4 ++ if 25% to 75% of cells were positive, and GPX4 +++ if more than 75% of cells were positive after IHC staining