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Renal cells in the context of ADPKD exhibit a wide range of metabolic abnormalities, including the decreased expression of system Xc- and reduced activity of GPX4, which are the necessary conditions and typical characteristics of ferroptosis [252, 253]

Additionally, proteins in this group exhibit binding affinities for small molecules (GO:0036094), carbohydrate derivatives (GO:0097367), and heterocyclic compounds (GO:1901363), underscoring their versatile roles in interacting with various biomolecules

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