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The FSP1/CoQ10/NADPH system protects cells from ferroptosis in a manner independent of the GPX4 axis by inhibiting lipid peroxidation and ferroptosis through the NAD(P)H-dependent reduction of CoQ10 to ubiquinol (CoQH 2 ) [23]

J Nutr 134:489492 Yamaoka Y, Takimura O (1990) Manufacture of glutathione with green algae Dunaliella

For decades, methotrexate has been used as a standard of care treatment for cancer patients (Newman and Maddocks, More recently, it has been established that the repression of tumor suppressor genes by methylation, which is dependent on SAM levels, is a key-initiating event for many cancers (Kulis and Esteller, De novo serine synthesis has also been identified as a metabolic vulnerability of many cancers, including non-small cell lung cancer (NSCLC), breast cancer, and melanoma (Locasale et al., Glycine metabolism has also been shown to be important in cancer development and growth

Yoon et al., 2012)