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Cholesterol can be synthesized endogenously and is present in all the body's cells, where it participates in many physiological functions, including fat metabolism, hormone production, vitamin D synthesis, and cell membrane integrity

(Studies have shown that everyone with an autoimmune disorder, including Hashimotos, has some degree of intestinal permeability

for example, IL-1 can damage endothelial tight junctions, inhibit astrocytic production of Sonic Hedgehog (SHH) signaling, and induce the release of further pro-inflammatory factors, thereby exacerbating neuroinflammation (Bronisz et al., 2023)