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While these model systems provide valuable insights into liver function and drug metabolism, they fail to mimic the intricate three-dimensional (3D) architecture, cellular heterogeneity, and zonation observed in the native liver

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When Nintendo shipped its latest handheld machine, the DSi, to North America last month, the Japanese giant continued a tradition of incremental upgrading of its fleet that began way back in the Game Boy Color days: Each new iteration retains enough of its predecessor to stay familiar, affordable and compatible while adding just enough new hotness to push buyers want! buttons