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319 Significantly, another phase II study of an orally active EGFR tyrosine kinase inhibitor (gefitinib) in combination with cisplatin offers promising efficacy as shown by evaluation of plasma EpsteinBarr virus DNA and a manageable safety profile for patients with metastatic or locoregionally recurrent NPC

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Crucially, tumor antigen-specific T lymphocytes demonstrated improved tumor growth-reducing capacities when stimulated in vitro with CoA and subsequently injected into transgenic mice expressing this antigen in pancreatic islet tumors (125)