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Additionally, around 12% of oxygen used in mitochondrial metabolism produces free radicals, which can lead to oxidative stress and even DNA damage [2]

The role of oxidative stress in the dysregulation of gene expression and protein metabolism in neurodegenerative disease

doi: 10.1186/s13020-016-0118-5 80 DhandayuthapaniSPerezHDParoulekAChinnakkannuPKandalamUJaffeMet al

The Montreal cohort is supported by grants from the National Institutes of Health (NIH) U19AI159819 and the Canadian Institutes of Health Research (CIHR) (PJT-173467) to N.S