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Chu C, Wang X, Yang C, Chen F, Shi L, Xu W, et al

titration helps identify the minimum effective dose for individual response [2]

The patients knew what they were receiving, and the outcomes were self-reported

Reported preclinical doses (for documentary purposes only) vary by route: intranasal (high bioavailability, direct BBB crossing via olfactory and trigeminal pathways), intraperitoneal, subcutaneous