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32 One study comparing the effects of leucocyte-rich PRP and corticosteroid injections for PRP found that PRP provided statistically important clinical improvements compared with corticosteroid injections at 12 weeks, but there was no control group and both groups were provided with a home program of advice and exercise

The critical implication of these findings is that OA should be reconceptualized, in a significant subset of patients, as a systemic metabolic disorder rather than a purely localized joint disease

After this initial period, injections are usually reduced to a maintenance schedule, typically administered once every one to three months, based on continued monitoring of your health status, symptoms, and follow-up blood tests

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