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This enhanced the C-X-C chemokine receptor 4 (CXCR4) expression downstream, upregulated the expression of HPV E6/E7 , and Ki-67 , and then promoted the metastasis of uterine cervical cancer cells to the lung (89)

Moreover, mTOR kinase activity may be suppressed by the activation of AMPK itself 11

As a signaling intermediate, elevated ROS levels can affect growth factor bioavailability by preventing extracellular matrix (ECM) synthesis, affecting bioavailability, participating in degradation of ECM components, promoting MMP production, and inducing chondrocyte death (40)

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