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Equilibrium : A state of balance between opposing forces

5.3 Disease-specific determinants of perinatal glucocorticoid sensitivity Multiple perinatal complications have been associated with fetal/neonatal dysregulation of the HPA axis, cortisol metabolism, and tissue GR expression and function ( Table 3 )

While the biological mechanisms governing this processclonal expansion, mutation, and competitive selection for survival signalsare well characterized, the quantitative principles that determine the optimal evolutionary trajectory of a B-cell lineage remain an active area of theoretical investigation

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